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A new study supported by the National Institutes of Health (NIH) suggests that sublingual immunotherapy (SLIT) can reduce the allergic response to peanut in adolescents and adults. SLIT is a treatment approach in which, under medical supervision, people place a small amount of allergen under the tongue to decrease their sensitivity to the allergen. This is one of the first randomized, placebo-controlled studies to test the efficacy and safety of SLIT to treat peanut allergy and is one of several federally funded trials investigating immune-based approaches to preventing and treating food allergy. The results appear online in the January issue of the Journal of Allergy and Clinical Immunology.
The study enrolled 40 people aged 12 to 37 years with peanut allergy who were on a peanut-free diet. After an initial food challenge to measure how much peanut powder they could eat without having an allergic reaction, participants received 44 weeks of daily therapy, followed by a second food challenge. Fourteen of the 20 participants (70 percent) given peanut SLIT were able to consume at least 10 times more peanut powder than they could at the beginning of the study, compared with only 3 of the 20 participants (15 percent) given placebo. After 68 weeks on peanut SLIT, on average, participants could consume significantly more peanut powder without having an allergic reaction. Study investigators also observed that SLIT caused only minor side effects, such as itching in the mouth, suggesting that daily therapy is safe.
Although more work is needed, the investigators hope that SLIT could one day help protect people with peanut allergy from experiencing severe allergic reactions in cases of accidental exposure. The researchers caution that people should not try peanut SLIT on their own because any form of immunotherapy carries a significant risk for allergic reactions. The therapy should be administered only under the guidance of trained clinicians.
The multicenter study was supported by the NIH’s National Institute of Allergy and Infectious Diseases (NIAID) and conducted by the Consortium of Food Allergy Research (CoFAR) at clinical sites in Baltimore; Chapel Hill, N.C.; Denver; Little Rock, Ark.; and New York City. CoFAR investigators David Fleischer, M.D., associate professor of pediatrics in the Division of Pediatric Allergy and Immunology at National Jewish Health in Denver, and A. Wesley Burks, M.D., chair of the Department of Pediatrics at the University of North Carolina, Chapel Hill, led the trial.
DM Fleischer et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. Journal of Allergy and Clinical Immunology DOI: 10.1016/j.jaci.2012.11.011 (2013).
Marshall Plaut, M.D., chief, Food Allergy, Atopic Dermatitis, and Allergic Mechanisms Section, NIAID’s Division of Allergy, Immunology, and Transplantation, is available to discuss this study.
NIAID conducts and supports research—at NIH, throughout the United States, and worldwide—to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating these illnesses. News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at www.niaid.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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This work was funded by NIAID, NIH, under grant numbers U19AI066738 and U01AI066560, and by the National Center for Research Resources and the National Center for Advancing Translational Sciences, NIH, under grant numbers UL1RR025780, UL1TR000067, UL1TR000039, UL1RR024128, and UL1RR025005. The ClinicalTrials.gov identifier for the study A Randomized, Double-Blind Placebo-Controlled Peanut Sublingual Immunotherapy Trial is NCT00580606.