In this summer edition of Ask the Ecz-perts, we talk campfires, poison ivy/oak, bug bites and heat rashes.
Published On: Feb 13, 2020
Last Updated On: Dec 10, 2020
In Ask the Ecz-perts, leading medical experts answer your most pressing questions about eczema and its related conditions.
In this edition of Ask the Eczperts, we asked leading medical professionals to answer your questions about dry skin, eczema and gut health, vaccines and Dupixent for seasonal allergies.
Follow these tips to combat dry skin:
Samantha B. Casselman, pediatric nurse practitioner at Phoenix Children’s Hospital
While there are still many unanswered questions here, there is reasonable evidence that suggests that gut health and skin health are closely related. Indeed, if you think about it, as you follow your skin to your lips, the same lining just continues on into your gut: it’s really all part of the same epithelium.
There are studies that suggest “leaky gut” (increased permeability of the gut) is related to the “leaky skin” (weak skin barrier) of eczema. We wrote an article about it a few years ago that has lots more information: https://nationaleczema.org/leaky-gut-and-atopic-dermatitis/
One important thing that I have learned is that to truly be healthy, all the systems have to be working well and working together, much like an orchestra. Many times, when one system starts to falter, others will follow, which is why we think a more holistic approach is always an important consideration.
Peter A. Lio, MD, assistant professor of clinical dermatology and pediatrics dermatology at Northwestern University Feinberg School of Medicine
Dupixent (dupulimab) is currently approved for both asthma and atopic dermatitis in patients over 12 years of age. Dupulimab has not been studied for seasonal allergies, however, in theory, it would improve both indicated conditions (asthma and atopic dermatitis) at the same time.
Dupixent, when studied for asthma, led to an increase in lung function and a decrease in severe asthma exacerbations, but it does not treat acute bronchospasm. You will still need your albuterol as needed. It was also used in patients with moderate to severe disease who were on inhaled corticosteroids for their asthma. There is no data if it would improve patients with mild asthma or seasonal allergies.
For the treatment of seasonal allergies, in theory, Dupixent should work as it blocks the interleukin (IL) 4 and IL13 pathways. But there is no data at the current time to prove it. When treating with dupulimab or potential other biologics, if the diseases use the same pathway (for allergies—Th2 pathway), the medication might work for multiple diseases as the medication is available systemically.
However, it is very important to remember that you cannot stop your asthma medications or other medications. You need to talk to your physician before you can wean off any medications as you might have increase of symptoms or side effects.
Jonathan Spergel, MD, PhD, chief of the allergy section at Children’s Hospital of Philadelphia
People with eczema are not more likely to have a vaccine reaction to these ingredients. Aluminum and thimersol are possible contact allergens in vaccines. If you suspect you have a contact allergy to these ingredients, then you should have patch testing done. Contact allergy to these ingredients is not a contraindication to vaccination.
There is no literature indicating eczema could get worse after vaccines. I was able to find a single case report of systemic contact dermatitis after a formaldehyde-containing vaccine indicating how rare this phenomenon is. Kuritzky LA, Pratt M. Systemic Allergic Contact Dermatitis After Formaldehyde-Containing Influenza Vaccination. J Cutan Med Surg. 2015 Sep-Oct;19(5):504-6
Kanwaljit K. Brar, MD, pediatric allergist and immunologist at National Jewish Health.