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People living with eczema are all too familiar with the persistent itch, redness and dry, scaly patches that can have a significant impact on daily life. Even though every person’s experience with this chronic condition is different, it is never too late to talk to a dermatologist about finding the right treatment plan that meets their needs.
A few years ago, actress, singer, and songwriter Mandy Moore noticed that the skin on her face was itchy, inflamed and peeling. She initially thought it had something to do with work or makeup, but when it persisted, she knew it was something more. After seeing a dermatologist, Mandy was diagnosed with atopic dermatitis, the most common form of eczema.
Mandy’s eczema is localized around her eyes. She recognizes she has a job where the redness and inflammation can be covered up during a flare, but knows firsthand how symptoms, like itching, can have an impact. “It never feels good to show up and not feel your best,” Moore said. That’s why she decided to partner with Incyte, a global pharmaceutical company, to launch “Moments of Clarity,” to highlight stories of people with eczema who have found relief from their symptoms and inspire others to talk to their dermatologist about treatment.
As part of the program, Mandy sat down with Anna, an active 12-year-old who is an avid basketball player, cheerleader and pianist. Anna also happens to have mild to moderate eczema. Anna explained to Mandy how her symptoms followed her throughout her life as a middle schooler, stating, “Some days I would wake up and I would just be like ‘Mom, can I not go to school today?’” She remembers trying what felt like countless different treatments for her eczema but hadn’t found the right option that worked for her. Anna added, “I just felt stuck.”
It was during a game of catch with her friends that Anna experienced her breaking point – she caught a football and her skin began to bleed. She ran to her mom to tell her they needed to do something to help her find relief. Shortly thereafter, Anna’s dermatologist recommended and prescribed OPZELURA®* (ruxolitinib) cream, which is indicated for short-term, non-continuous treatment of mild to moderate eczema in people 12 and older without weakened immune systems and not well controlled on topical prescription therapies or when those therapies are not recommended. The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
Anna’s mom, Rachael, recalls how things changed after Anna started the treatment. “After Anna started Opzelura, we noticed that she was not as bothered by her symptoms – less itchiness, less redness, and certainly less inflammation.”
See below for IMPORTANT SAFETY INFORMATION including boxed Warning for Serious Infections, Increased Risk of Death, Lymphoma and other Cancers, Major Cardiovascular Events, and Blood Clots.
Rachael’s advice for other parents going through a similar experience? She emphasizes the importance of open communication with a dermatologist, stating, “number one, be patient. Number two, talk with your dermatologist about your different options. Everybody’s experience is their own.”
To learn more and hear the inspiring stories of people living with and caring for someone with mild to moderate eczema and how they found relief, visit MyMomentsofClarity.com.
*Mandy Moore is not prescribed OPZELURA.
All individuals have been compensated for their participation.
IMPORTANT SAFETY INFORMATION
OPZELURA is for use on the skin only. Do not use OPZELURA in your eyes, mouth, or vagina.
OPZELURA may cause serious side effects, including:
Serious Infections: OPZELURA contains ruxolitinib. Ruxolitinib belongs to a class of medicines called Janus kinase (JAK) inhibitors. JAK inhibitors are medicines that affect your immune system. JAK inhibitors can lower the ability of your immune system to fight infections. Some people have had serious infections while taking JAK inhibitors by mouth, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses that can spread throughout the body. Some people have been hospitalized or died from these infections. Some people have had serious infections of their lungs while taking OPZELURA. Your healthcare provider should watch you closely for signs and symptoms of TB during treatment with OPZELURA.
OPZELURA should not be used in people with an active, serious infection, including localized infections. You should not start using OPZELURA if you have any kind of infection unless your healthcare provider tells you it is okay. You may be at a higher risk of developing shingles (herpes zoster) while using OPZELURA.
Increased risk of death due to any reason (all causes): Increased risk of death has happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and are taking a medicine in the class of medicines called JAK inhibitors by mouth.
Cancer and immune system problems: OPZELURA may increase your risk of certain cancers by changing the way your immune system works. Lymphoma and other cancers have happened in people taking a medicine in the class of medicines called JAK inhibitors by mouth. People taking JAK inhibitors by mouth have a higher risk of certain cancers including lymphoma and lung cancer, especially if they are a current or past smoker. Some people have had skin cancers while using OPZELURA. Your healthcare provider will regularly check your skin during your treatment with OPZELURA. Limit the amount of time you spend in the sunlight. Wear protective clothing when you are in the sun and use a broad-spectrum sunscreen.
Increased risk of major cardiovascular events: Increased risk of major cardiovascular events such as heart attack, stroke, or death have happened in people 50 years of age and older who have at least 1 heart disease (cardiovascular) risk factor and taking a medicine in the class of medicines called JAK inhibitors by mouth, especially in current or past smokers.
Blood clots: Blood clots in the veins of your legs (deep vein thrombosis, DVT) or lungs (pulmonary embolism, PE) can happen in some people taking OPZELURA. This may be life-threatening. Blood clots in the vein of the legs (deep vein thrombosis, DVT) and lungs (pulmonary embolism, PE) have happened more often in people who are 50 years of age and older and with at least 1 heart disease (cardiovascular) risk factor taking a medicine in the class of medicines called JAK inhibitors by mouth.
Low blood cell counts: OPZELURA may cause low platelet counts (thrombocytopenia), low red blood cell counts (anemia), and low white blood cell counts (neutropenia). If needed, your healthcare provider will do a blood test to check your blood cell counts during your treatment with OPZELURA and may stop your treatment if signs or symptoms of low blood cell counts happen.
Cholesterol increases: Cholesterol increase has happened in people when ruxolitinib is taken by mouth. Tell your healthcare provider if you have high cholesterol or triglycerides.
Before starting OPZELURA, tell your healthcare provider if you:
After starting OPZELURA:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of OPZELURA in people treated for atopic dermatitis include: common cold (nasopharyngitis), diarrhea, bronchitis, ear infection, increase in a type of white blood cell (eosinophil) count, hives, inflamed hair pores (folliculitis), swelling of the tonsils (tonsillitis), and runny nose (rhinorrhea).
These are not all of the possible side effects of OPZELURA. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Incyte Corporation at 1-855-463-3463.
INDICATION AND USAGE
OPZELURA is a prescription medicine used on the skin (topical) for the short-term and non-continuous chronic treatment of mild to moderate eczema (atopic dermatitis) in non-immunocompromised adults and children 12 years of age and older whose disease is not well controlled with topical prescription therapies or when those therapies are not recommended.
The use of OPZELURA along with therapeutic biologics, other JAK inhibitors, or strong immunosuppressants such as azathioprine or cyclosporine is not recommended.
It is not known if OPZELURA is safe and effective in children less than 12 years of age with atopic dermatitis.
Please see the Full Prescribing Information, including Boxed Warning, and Medication Guide for OPZELURA.
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OPZELURA is a registered trademark of Incyte.
© 2023, Incyte Corporation. MAT-OPZ-01901 11/23