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Clinical Trial Details for Study Evaluating Efficacy and Safety of PF-04965842 and Dupilumab in Adult Subjects With Moderate to Severe Atopic Dermatitis on Background Topical Therapy


Pfizer
NCT ID: NCT03720470
Last Updated: August 20, 2019

The Study at a Glance

  • Status: Recruiting
  • Phase: Phase 3
  • Gender: All
  • Age: 18 Years - N/A
  • Condition:
    • Dermatitis
    • Dermatitis, Atopic
    • Eczema
    • Skin Diseases
    • Skin Diseases, Genetic
    • Genetic Diseases, Inborn
    • Skin Diseases, Eczematous
    • Hypersensitivity
    • Hypersensitivity, Immediate
    • Immune System Diseases
  • Study Type: Interventional
  • Intervention:
  • Lead Sponsor: Pfizer
  • Location: Not Provided

Official Title

A PHASE 3 RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO-CONTROLLED, PARALLEL GROUP, MULTI-CENTER STUDY INVESTIGATING THE EFFICACY AND SAFETY OF PF-04965842 AND DUPILUMAB IN COMPARISON WITH PLACEBO IN ADULT SUBJECTS ON BACKGROUND TOPICAL THERAPY, WITH MODERATE TO SEVERE ATOPIC DERMATITIS

Purpose

B7451029 is a Phase 3 study to investigate PF-04965842 in adult patients who have moderate to severe atopic dermatitis and use background topical therapy. The efficacy of two dosage strengths of PF-04965842, 100 mg and 200 mg taken orally once daily will be evaluated relative to placebo over 12 weeks. The efficacy of the two dosage strengths of PF-04965842 will be compared with dupilumab in terms of pruritus relief at 2 weeks. The two dosage strengths of PF-04965842 and dupilumab 300 mg injected subcutaneously once every two weeks (with a loading dose of 600 mg injected on the first day) will also be evaluated relative to placebo over 16 weeks. The safety of the investigational products will be evaluated over the duration of the study. Subjects will use non-medicated emollient at least twice a day and medicated topical therapy such as corticosteroids, calcineurin inhibitors or PDE4 inhibitors, as per protocol guidance, to treat active lesions during the study. Subjects who are randomized to receive one of the two dosage strengths of PF-04965842 will also receive placebo injectable study drug every two weeks until Week 16 and then will continue on receiving only the oral study drug for 4 weeks. Subjects who are randomized to receive dupilumab injections every two weeks will also receive oral placebo to be taken once daily until Week 16 and will then continue to receive only the oral placebo for 4 weeks. Subjects who are randomized to the placebo arms, will receive both daily oral placebo and injectable placebo every two weeks until Week 16, after which they will receive either 100 mg or 200 mg of PF-04965842 taken orally once daily for 4 weeks, dependent upon which arm they have been allocated to. Eligible subjects will have an option to enter a long-term extension study after completing 20 weeks of treatment.

Eligibility

Ages Eligible for Study

18 Years to N/A

Sexes Eligible for Study

All

Accepts Healthy Volunteers

No

Criteria

Inclusion Criteria:

– Male or female subjects aged 18 years or older at the time of informed consent

– Diagnosis of atopic dermatitis (AD) for at least 1 year and current status of moderate
to severe disease (>= the following scores: BSA 10%, IGA 3, EASI 16, Pruritus NRS
severity 4)

– Documented recent history (within 6 months before the screening visit) of inadequate
response to treatment with medicated topical therapy for AD for at least 4 weeks, or
who have required systemic therapies for control of their disease.

– Must be willing and able to comply with standardized background topical therapy, as
per protocol guidelines throughout the study

– Female subjects who are of childbearing potential must not be intending to become
pregnant, currently pregnant, or lactating. The following conditions apply:

1. Female subjects of childbearing potential must have a confirmed negative
pregnancy test prior to randomization;

2. Female subjects of childbearing potential must agree to use a highly effective
method of contraception for the duration of the active treatment period and for
at least 28 days after the last dose of investigational product.

– Female subjects of non-childbearing potential must meet at least 1 of the following
criteria:

– Have undergone a documented hysterectomy and/or bilateral oophorectomy;

– Have medically confirmed ovarian failure; or

– Achieved postmenopausal status, defined as follows: cessation of regular menses
for at least 12 consecutive months with no alternative pathological or
physiological cause and have a serum follicle stimulating hormone (FSH) level
confirming the postmenopausal state.

All other female subjects (including female subjects with tubal ligations) are considered
to be of childbearing potential.

-If receiving concomitant medications for any reason other than AD, must be on a stable
regimen prior to Day 1 and through the duration of the study

Exclusion Criteria:

– Other acute or chronic medical or psychiatric condition including recent (within the
past year) or active suicidal ideation or behavior or laboratory abnormality that may
increase the risk associated with study participation or investigational product
administration or may interfere with the interpretation of study results and, in the
judgment of the investigator, would make the subject inappropriate for entry into this
study

– Medical history including thrombocytopenia, coagulopathy or platelet dysfunction, Q
wave interval abnormalities, current or history of certain infections, cancer,
lymphoproliferative disorders and other medical conditions at the discretion of the
investigator

– Unwilling to discontinue current AD medications prior to the study or require
treatment with prohibited medications during the study

– Other active nonAD inflammatory skin diseases or conditions affecting skin

– Prior treatment with JAK inhibitors

– Previous treatment with dupilumab

– Unwilling to discontinue current AD medications prior to the study or require
treatment with prohibited medications during the study

Additional Information, Locations & Contacts

Sponsors & Collaborators

Pfizer

Investigators

Study Director: Pfizer CT.gov Call Center

Pfizer

Please refer to this study by its ClinicalTrials.gov identifier: NCT03720470

Location

Contacts

Clinical Research Center of Alabama, LLC

Birmingham, Alabama 35209

United States

The University Of Alabama At Birmingham

Birmingham, Alabama 35233

United States

Marvel Research, LLC

Huntington Beach, California 92647

United States

Alliance Research Centers

Laguna Hills, California 92653

United States

Allergy & Asthma Care Center of Southern California

Long Beach, California 90808

United States

Advanced Research Center, Inc. - Los Alamitos Site

Los Alamitos, California 90720

United States

Allergy & Asthma Associates of Southern California dba Southern California Research

Mission Viejo, California 92691

United States

Dermatology Specialists, Inc.

Murrieta, California 92562

United States

MedDerm Associates

San Diego, California 92103

United States

Clinical Science Institute

Santa Monica, California 90404

United States

Synexus Clinical Research US, Inc.

Santa Rosa, California 95405

United States

IMMUNOe Research Centers

Centennial, Colorado 80112

United States

Renaissance Research and Medical Group, Inc

Cape Coral, Florida 33991

United States

C & R Research Servcies USA, Inc.

Coral Gables, Florida 33134

United States

Florida Academic Centers Research and Education, LLC

Coral Gables, Florida 33134

United States

Moonshine Research Center, Inc.

Doral, Florida 33166

United States

Wellness Clinical Research, LLC

Hialeah, Florida 33012

United States

Solutions Through Advanced Research, Inc.

Jacksonville, Florida 32256

United States

Olympian Clinical Research

Largo, Florida 33770

United States

Savin Medical Group LLC

Miami, Florida 33126

United States

Forward Clinical Trials, Inc. dba ForCare Clinical Research

Tampa, Florida 33613

United States

Research Institute of Southeast, LLC

West Palm Beach, Florida 33401

United States

Research Institute of the Southeast, LLC

West Palm Beach, Florida 33401

United States

Columbus Regional Research Institute

Columbus, Georgia 31904

United States

Advanced Medical Research, PC

Sandy Springs, Georgia 30328

United States

Idaho Allergy and Research

Eagle, Idaho 83616

United States

ASR, LLC

Nampa, Idaho 83687

United States

Great Lakes Clinical Trials

Chicago, Illinois 60640

United States

Midwest Allergy Sinus Asthma, SC

Normal, Illinois 61761

United States

NorthShore University HealthSystem

Skokie, Illinois 60077

United States

Southern Illinois University School of Medicine

Springfield, Illinois 62702

United States

Dundee Dermatology

West Dundee, Illinois 60118

United States

Deaconess Clinic Downtown

Evansville, Indiana 47713

United States

The Indiana Clinical Trials Center

Plainfield, Indiana 46168

United States

Forefront Dermatology, S.C.

Louisville, Kentucky 40202

United States

Meridian Clinical Research, LLC

Baton Rouge, Louisiana 70808

United States

Callender Center for Clinical Research LLC.

Glenn Dale, Maryland 20769

United States

DermAssociates, LLC

Rockville, Maryland 20850

United States

TrialSpark - Ronald Shore, MD

Rockville, Maryland 20852

United States

Clarkston Skin Research

Clarkston, Michigan 48346

United States

Clinical Research Institute, Inc.

Plymouth, Minnesota 55441

United States

Skin Laser and Surgery Specialists of NY and NJ

Hackensack, New Jersey 07601

United States

Forest Hills Dermatology Group

Forest Hills, New York 11375

United States

Juva Skin and Laser Center

New York, New York 10022

United States

TrialSpark, Inc (Russell Cohen)

Oceanside, New York 11572

United States

Cary Dermatology Center, PA

Cary, North Carolina 27511

United States

PMG Research of Raleigh, LLC d/b/a PMG Research of Cary

Cary, North Carolina 27518

United States

Maeve E. O'Connor, MD, PA d/b/a Allergy Asthma & Immunology Research Institute

Charlotte, North Carolina 28204

United States

Medication Management, LLC

Greensboro, North Carolina 27408

United States

PMG Research Inc., d/b/a PMG Research of Piedmont HealthCare

Statesville, North Carolina 28625

United States

PMG Research of Winston-Salem, LLC

Winston-Salem, North Carolina 27103

United States

Winston-Salem Dermatology and Surgery Center, PLLC

Winston-Salem, North Carolina 27103

United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106

United States

Newton Clinical Research

Oklahoma City, Oklahoma 73120

United States

Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma 74136

United States

Portland Clinical Research dba Columbia Allergy & Asthma Clinic

Clackamas, Oregon 97015

United States

Crisor, LLC

Medford, Oregon 97504

United States

Valley Immediate Care

Medford, Oregon 97504

United States

Oregon Health & Science University (OHSU)

Portland, Oregon 97239

United States

Paddington Testing Co, Inc.

Philadelphia, Pennsylvania 19103

United States

Synexus Clinical Research US, Inc.

Anderson, South Carolina 29621

United States

Clinical Research Center of the Carolinas

Charleston, South Carolina 29407

United States

Synexus Clinical Research US. Inc.

Greer, South Carolina 29651

United States

Health Concepts

Rapid City, South Dakota 57702

United States

Arlington Research Center, Inc.

Arlington, Texas 76011

United States

Austin Institute for Clinical Research, Inc.

Austin, Texas 78705

United States

Center for Clinical Studies, LTD. LLP

Houston, Texas 77004

United States

Center for Clinical Studies, LTD. LLP

Webster, Texas 77598

United States

Jordan Valley Dermatology Center

West Jordan, Utah 84088

United States

Summit Clinical Research, LLC

Franklin, Virginia 23851

United States

West Virginia Research Institute

Morgantown, West Virginia 26505

United States

Woden Dermatology

Phillip, Australian Capital Territory 2606

Australia

Australian Clinical Research Network

Maroubra, New South Wales 2035

Australia

The Skin Centre

Benowa, Queensland 4217

Australia

Veracity Clinical Research Pty Ltd

Woolloongabba, Queensland 4102

Australia

Box Hill Hospital

Box Hill, Victoria 3128

Australia

Skin and Cancer Foundation Inc

Carlton, Victoria 3053

Australia

Sinclair Dermatology

East Melbourne, Victoria 3002

Australia

Royal Melbourne Hospital

Parkville, Victoria 3050

Australia

Emeritus Research

Camberwell, VIC 3124

Australia

North Eastern Health Specialists

Hectorville, South Australia, 5073

Australia

UMHAT Dr. Georgi Stranski EAD,

Pleven, 5804

Bulgaria

DCC 2/Sofia EOOD

Sofia, 1000

Bulgaria

"Acibadem City Clinic MHAT Tokuda" EAD

Sofia, 1407

Bulgaria

"DCC Aleksandrovska" EOOD

Sofia, 1431

Bulgaria

DCC "Alexandrovska" EOOD

Sofia, 1431

Bulgaria

Medical Center Doverie AD

Sofia, 1632

Bulgaria

Dermatology Clinic "Sofia" - group practice for specialized outpatient medical care

Sofia, 1756

Bulgaria

"Mc Synexus Sofia" Eood

Sofia, 1784

Bulgaria

Medical Centre Synexus Sofia EOOD-branch Stara Zagora

Stara Zagora, 6000

Bulgaria

"DCC "Mladost-M Varna" OOD

Varna, 9000

Bulgaria

Pacific Dermaesthetics Inc.

Vancouver, British Columbia V6H4E1

Canada

Wiseman Dermatology Research Inc.

Winnipeg, Manitoba R3M3Z4

Canada

DermEffects

London, Ontario N6H 5L5

Canada

Lynderm Research Inc.

Markham, Ontario L3P 1X2

Canada

North Bay Dermatology Centre

North Bay, Ontario P1B 3Z7

Canada

SKiN Centre for Dermatology

Peterborough, Ontario K9J5K2

Canada

Toronto Research Centre

Toronto, Ontario M3H5Y8

Canada

AvantDerm Clinical Research

Toronto, Ontario M5A 3R6

Canada

Manna Research (Toronto)

Toronto, Ontario M9W 4L6

Canada

Innovaderm Research Inc.

Montreal, Quebec H2K 4L5

Canada

Dr. Rachel Asiniwasis Medical Prof Corp

Regina, Saskatchewan S4V1R9

Canada

Centro Medico SkinMed Limitada

Santiago, Region Metropolitana 7580206

Chile

Clinica Dermacross S.A.

Santiago, Region Metropolitana 7640881

Chile

Centro Internacional de Estudios Clinicos - CIEC

Santiago, Region Metropolitana 8420383

Chile

MIRES (M y F Estudios Clínicos Limitada)

Santiago, Región Metropolitana 7750495

Chile

LANCIER COMPANY s.r.o.

Brno 2, 602 00

Czechia

CCR Czech Brno, s.r.o.

Brno, 602 00

Czechia

Dermamedica S.R.O.

Nachod, 547 01

Czechia

Lekarna U Stribrneho orla

Nachod, 547 01

Czechia

CCBR Ostrava s.r.o.

Ostrava, 702 00

Czechia

Lekarna Rezidence Nova Karolina

Ostrava, 702 00

Czechia

BENU Lekarna

Pardubice, 530 02

Czechia

CCR Czech, a.s.

Pardubice, 530 02

Czechia

Nemocnice Pardubického kraje, a.s., Pardubická nemocnice

Pardubice, 532 03

Czechia

Pharmacy: Nemocnice Pradubickeho kraje, a s,

Pardubice, 532 03

Czechia

Lékárna Pod platany

Praha 10, 101 00

Czechia

Sanatorium profesora Arenbergera

Praha 1, 11000

Czechia

Lekarna Cisarska

Praha 2, 120 00

Czechia

Lekarna U sv. Ignace

Praha 2, 120 00

Czechia

Synexus Czech, s.r.o.

Praha 2, 120 00

Czechia

CCR Prague, s.r.o.

Praha 3, 130 00

Czechia

CHU Besancon - Hopital Jean Minjoz

Besancon, 25000

France

CHU de Bordeaux - Hopital Saint Andre

Bordeaux, 33075

France

Hopital Morvan-CHU Brest- Service Hematologie Clinique

Brest, 29200

France

Service de Radiologie

Brest, 29200

France

Centre Hospitalier Le Mans

Le Mans, 72000

France

CHU de Nantes

Nantes cedex 01, 44093

France

Service de Radiologie Centrale - CHU de Nantes

Nantes cedex 01, 44093

France

Hôpital Lyon Sud

Pierre Bénite Cedex, 69495

France

Licca Clinical Research Institute

Augsburg, Bavaria 86179

Germany

SIBAmed Studienzentrum GmbH & Co KG

Leipzig, Saxony 04103

Germany

Fachklinik Bad Bentheim

Bad Bentheim, 48455

Germany

Rothhaar Studien GmbH

Berlin, 10783

Germany

Klinikum Bielefeld Rosenhoehe

Bielefeld, 33647

Germany

Universitätsklinikum Bonn AöR

Bonn, 53105

Germany

Klinische Forschung Dresden GmbH

Dresden, 01069

Germany

Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden

Dresden, 01307

Germany

IKF Pneumologie GmbH & Co KG, Institut fuer klinische Forschung

Frankfurt, 60596

Germany

Universitätsklinikum und Poliklinik für Dermatologie und Venerologie

Halle, 06120

Germany

Universitaetsklinikum Schleswig-Holstein, Campus Kiel

Kiel, 24105

Germany

Studienzentrum Dr. med. Beate Schwarz

Langenau, 89129

Germany

Universitaetsklinikum Schleswig-Holstein/Campus Luebeck

Luebeck, 23538

Germany

Dermatologische Gemeinschaftspraxis Dres. Scholz, Sebastian, Schilling

Mahlow, 15831

Germany

Universitätsklinikum Marburg

Marburg, 35043

Germany

University of Muenster

Muenster, 48149

Germany

SE AOK Bor-, Nemikortani es Boronkologiai Klinika

Budapest, 1085

Hungary

Synexus Magyarország Egészségügyi Szolgáltató Kft.

Debrecen, 4025

Hungary

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032

Hungary

Synexus Magyarország Egészségügyi Szolgáltató Kft. Synexus Gyula DRS

Gyula, 5700

Hungary

Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz

Nyíregyháza, 4400

Hungary

Pecsi Tudomanyegyetem Klinikai Kozpont, Bor-,Nemikortani es Onkodermatologiai Klinika

Pecs, 7632

Hungary

Trial Pharma Kft.

Püspökladány, 4150

Hungary

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

Szeged, 6720

Hungary

Medmare Bt

Veszprem, 8200

Hungary

Synexus Magyarország Egészségügyi Kft.

Zalaegerszeg, 8900

Hungary

Istituto San Gallicano

Roma, RM 00144

Italy

Fondazione Policlinico Universitario A. Gemelli IRCCS

Rome, RM 00168

Italy

AOU di Modena

Modena, 41124

Italy

Kawashima Dermatology Clinic

Ichikawa, Chiba 272-0033

Japan

Takagi Dermatological Clinic

Obihiro, Hokkaido 080-0013

Japan

Dermatology Shimizu Clinic

Kobe, Hyogo 657-0846

Japan

Noguchi Dermatology Clinic

Kamimashiki-gun, Kumamoto 861-3101

Japan

Osaka Habikino Medical Center

Habikino, Osaka 583-8588

Japan

Kume Clinic

Sakai, Osaka 593-8324

Japan

Jichi Medical University Hospital

Shimotsuke-shi, Tochigi 329-0498

Japan

Iidabashi Skin Clinic

Chiyoda-ku, Tokyo 102-0072

Japan

Fukuwa Clinic

Chuo-ku, Tokyo 103-0027

Japan

Tokyo Medical University Hospital

Shinjyuku-ku, Tokyo 160-0023

Japan

Hoshikuma Dermatology・Allergy Clinic

Fukuoka, 814-0171

Japan

Matsuda Tomoko Dermatological Clinic

Fukuoka, 819-0167

Japan

Sanrui Hifuka

Saitama, 330-0854

Japan

Korea University Ansan Hospital

Ansan-si, Gyeonggi-do 15355

Korea, Republic of

Soon Chun Hyang University Bucheon Hospital

Bucheon-si, Gyeonggi-do 14584

Korea, Republic of

Chungnam National University Hospital CNUH

Daejeon, 35015

Korea, Republic of

The Catholic University of Korea, Incheon St. Mary's Hospital

Incheon, 21431

Korea, Republic of

Severance Hospital, Yonsei Univ. Health System

Seoul, 03722

Korea, Republic of

Chung-Ang University Hospital

Seoul, 06973

Korea, Republic of

Hallym University Kangnam Sacred Heart Hospital

Seoul, 07441

Korea, Republic of

Selga Freiberga private practice in dermatovenerology and cosmetology

Jelgava, LV-3001

Latvia

Riga 1st Hospital, Clinic for Dermatology and STD

Riga, LV-1001

Latvia

Aesthetic dermatology clinic of Prof. J. Kisis

Riga, LV-1003

Latvia

Childrens Clinical University Hospital State SLLC

Riga, LV-1004

Latvia

Health and aesthetics Ltd

Riga, LV-1009

Latvia

Outpatient Clinic of Ventspils

Ventspils, LV-3601

Latvia

Cryptex Investigación Clínica, S.A. de C.V.

Cuauhtemoc, Mexico CITY 06100

Mexico

Arke Estudios Clinicos Sa De Cv

Cuauhtemoc, Mexico CITY 06700

Mexico

Eukarya PharmaSite

Monterrey, Nuevo LEON 64718

Mexico

SMIQ. S. de R. L. de C.V.

Queretaro, 76070

Mexico

NZOZ Specjalistyczny Osrodek Dermatologiczny "DERMAL"

Bialystok, 15-453

Poland

Centrum Medyczne SENSEMED

Chorzow, 41-500

Poland

Synexus Polska Sp. z o.o. Oddzial w Czestochowie

Czestochowa, 42-202

Poland

COPERNICUS-SZPITAL Oddzial Dermatologii

Gdansk, 80-152

Poland

Uniwersyteckie Centrum Kliniczne, Klinika Dermatologii, Wenerologii i Alergologii

Gdansk, 80-214

Poland

Synexus Polska Sp. z o.o. Oddzial w Gdyni

Gdynia, 81-537

Poland

MCBK

Grodzisk Mazowiecki, 05-825

Poland

Synexus Polska Sp. z o.o. Oddzial w Katowicach

Katowice, 40-040

Poland

Care Clinic Centrum Medyczne

Katowice, 40-568

Poland

Centrum Medyczne Angelius Provita

Katowice, 40-611

Poland

Pro Familia Altera Sp. z o.o.

Katowice, 40-648

Poland

Gabinet Dermatologiczny Beata Krecisz

Kielce, 25-155

Poland

Centrum Medyczne Plejady

Krakow, 30-363

Poland

AWP Klinika Dermatologii Pod Fortem Anna Wojas-Pelc

Krakow, 31-302

Poland

Krakowskie Centrum Medyczne Sp. z o.o.

Krakow, 31-501

Poland

Centrum Medyczne Promed

Krakow, 31-513

Poland

Prywatna Praktyka Lekarska - Adam Smialowski

Ksawerow, 95-054

Poland

Dermoklinika-Centrum Medyczne s.c. M. Kierstan, J. Narbutt, A. Lesiak

Lodz, 90-436

Poland

Salve Medica Sp. z o.o. Sp. k.

Lodz, 91-211

Poland

KO-MED Centra Kliniczne Lublin II

Lublin, 20-362

Poland

NZOZ "Med-Laser" Borzecki Spolka Jawna

Lublin, 20-406

Poland

Dermedic Jacek Zdybski

Ostrowiec Swietokrzyski, 27-400

Poland

Synexus Polska Sp. z o.o. Oddzial w Poznaniu

Poznan, 60-702

Poland

Clinical Research Center Spolka z ograniczona odpowiedzialnoscia MEDIC-R Sp.k.

Poznan, 60-848

Poland

LIFT-MED Spolka Akcyjna

Rybnik, 44-200

Poland

Kliniczny Szpital Wojewodzki nr 1 im. F. Chopina, Klinika Dermatologii

Rzeszow, 35-055

Poland

EMED Centrum Uslug Medycznych Ewa Smialek

Rzeszow, 35-205

Poland

Twoja Przychodnia - Szczecinskie Centrum Medyczne

Szczecin, 71-434

Poland

Medycyna Kliniczna

Warszawa, 00-874

Poland

Synexus Polska Sp. z o.o. Oddzial w Warszawie

Warszawa, 01-192

Poland

Centrum Medyczne AMED

Warszawa, 01-518

Poland

MTZ Clinical Research Sp. z o.o.

Warszawa, 02-106

Poland

RCMed Oddzial Warszawa

Warszawa, 02-657

Poland

Carpe Diem Centrum Medycyny Estetycznej

Warszawa, 02-661

Poland

"REUMATIKA - Centrum Reumatologii" NZOZ

Warszawa, 02-691

Poland

Klinika Ambroziak Sp. z o.o.

Warszawa, 02-758

Poland

EMC Instytut Medyczny S.A. Przychodnia przy ul. Lowieckiej

Wroclaw, 50-220

Poland

Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

Wroclaw, 50-381

Poland

Lukasz Matusiak "4Health"

Wroclaw, 50-566

Poland

Centrum Medyczne Oporow

Wroclaw, 52-416

Poland

SUMMIT CLINICAL RESEARCH, s.r.o.

Bratislava, 831 01

Slovakia

Nemocnica Kosice-Saca, a.s., 1. sukromna nemocnica

Kosice-Saca, 040 15

Slovakia

Pedi-Derma s.r.o.

Kosice, 04001

Slovakia

Fakultna nemocnica s poliklinikou Nove Zamky, Dermatovenerologicka Klinika

Nove Zamky, 940 34

Slovakia

SANARE spol. s.r.o., Dermatovenerologicka ambulancia

Svidnik, 089 01

Slovakia

Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona 08916

Spain

Hospital Universitario Fundacion Alcorcon

Alcorcon, Madrid 28922

Spain

Hospital Universitario Puerta de Hierro de Majadahonda

Majadahonda, Madrid 28222

Spain

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Madrid 28222

Spain

Hospital Universitario 12 de Octubre

Madrid, 28041

Spain

Hospital Universitario y Politecnico La Fe

Valencia, 46026

Spain

Taipei Veterans General Hospital

Taipei, Taiwan (r.o.c) 11217

Taiwan

Chung Shan Medical University Hospital (CSMUH)

Taichung City, 40201

Taiwan

Taichung Veterans General Hospital

Taichung, 40705

Taiwan

National Cheng-Kung University Hospital

Tainan, 704

Taiwan

National Taiwan University Hospital

Taipei, 100

Taiwan

Mackay Memorial Hospital

Taipei, 10449

Taiwan

Medinova Research -West London Dedicated Research Centre

Wokingham, Berkshire RG40 1XS

United Kingdom

Derriford Hospital

Plymouth, Devon PL6 8DH

United Kingdom

Medinova Research, East London Dedicated Research Centre

Romford, Essex RM1 3PJ

United Kingdom

Guy's Hospital-Guy's and St Thomas NHS Foundation Trust

London, Greater London SE1 9RT

United Kingdom

MeDiNova South London Clinical Studies Centre

Sidcup, Kent DA14 6LT

United Kingdom

MeDiNova Research North London Dedicated Research Centre

Northwood, Middlesex HA6 2RN

United Kingdom

MeDiNova Lakeside, Dedicated Research Centre

Corby, Northamptonshire NN17 2UR

United Kingdom

Medinova Research

Yaxley, Peterborough PE7 3JL

United Kingdom

Medinova Research, Warwickshire Dedicated Research Centre

Kenilworth, Warwickshire CV8 1JD

United Kingdom

West Glasgow ACH, NHS Greater Glasgow and Clyde

Glasgow, G3 8SJ

United Kingdom

MeDiNova Yorkshire Dedicated Research Centre

Shipley, BD18 3SA

United Kingdom