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Interferon Responses in Eczema Herpeticum


National Institute of Allergy and Infectious Diseases

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National Institute of Allergy and Infectious Diseases Identifier:



Atopic dermatitis (AD) is a chronic skin disorder characterized by recurrent viral skin infections. Some individuals with AD can get eczema herpeticum (disseminated herpes simplex infection). Interferon (IFN)-γ plays a critical role in the innate and acquired immune responses and has been shown to be significantly decreased after stimulation with HSV ex vivo. The purpose of this study is to determine if deficient IFN-γ induction leads to susceptibility to HSV infection in ADEH+ patients.


Ages Eligible for Study:           6 Years to 65 Years

Genders Eligible for Study:     Both

Accepts Healthy Volunteers: Yes



Inclusion Criteria:

History of AD with or without eczema herpeticum as diagnosed using the Atopic Dermatitis Research Network (ADRN) Standard Diagnostic Criteria OR who are non-atopic as diagnosed using the ADRN Standard Diagnostic Criteria.

Exclusion Criteria:

Systemic illness not being studied (eg. HIV, lupus)

Active systemic malignancy (other than uncomplicated non-melanoma skin cancer)

Skin disease other than AD that would impact the barrier function (eg. psoraisis, bullous disease)

First degree relative in study

Deemed not eligible by investigator



Denver, Colorado

Principal investigator

Donald Leung, MD, PhD (National Jewish Health)

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