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National Human Genome Research Institute (NHGRI)
National Institutes of Health Clinical Center (CC)
The goal of this study is to examine the microbes (bateria, fungi, viruses) that live on human skin and the impact of these microbes on health and disease. The study will analyze healthy human skin and compare that to skin of individuals with atopic dermatitis (eczema).
Ages Eligible for Study: 2 years-40 years
Genders Eligible for Study: Both
Accepts Healthy Volunteers: Yes
All individuals must have a primary care physician who will continue standard care.
Healthy Adult Volunteers- age 18-40 at time of enrollment
Atopic Dermatitis Patients- confirmed diagnosis, mild-moderate disease, at least 1 involved antecubital fossa or popliteal fossa at time of enrollment
Healthy Pediatric Volunteers- age 2-18 years at time of enrollment
Unstable or uncontrolled medical conditions, receiving or planning to receive IND agent, UV light therapy, monoclonal antibodies, or systemic immunosuppressants less than 7 days or 5 half-lives before starting protocol, cancer and treated with chemotherapy or radiation therapy in last 6 months, history of bone marrow transplant or gene therapy.
Specific Exclusion Criteria for Atopic Dermatitis Patients- unable to remain off of oral steroids or antibiotics for 7 days prior to sampling, unable to temporarily discontinue topical steroids and calcineurin inhibitors for at least 7 days to sampling site, underlying immunodeficiency,
National Institutes of Health (Bethesda, MD)
Julie A. Segre, Ph.D. (National Human Genome Research Institute)