Can Squalane Help Eczema?

Squalane is a popular ingredient that’s been popping up in many skincare products. But is it helpful — and safe — for people with eczema? We went straight to the experts, in this case two dermatologists, to find out.

What is squalane?

Squalane is a hydrogenated version of squalene, a naturally occurring lipid found in human sebum, explained Dr. Marisa Garshick, a board-certified dermatologist at MDCS Dermatology: Medical Dermatology and Cosmetic Surgery in New York City and New Jersey. “It is used in skincare products for its moisturizing and antioxidant properties, making it stable and effective in various formulations,” she said.

That might have you wondering what the difference is between squalane and squalene. “Squalene is naturally produced by sebaceous glands and is part of our skin’s sebum, helping to keep the skin moisturized,” Dr. Garshick said. “Squalane, on the other hand, is a hydrogenated form of squalene, making it more stable and suitable for use in skincare products without oxidizing when exposed to air.”

How does squalane work on your skin? What are the known benefits?

Because squalane is a lipid and mimics squalene, it hydrates the skin and reinforces the integrity of the skin that will prevent water loss, explained Dr. Paul Yamauchi, medical director at the Dermatology Institute & Skin Care Center in Santa Monica, CA, and clinical assistant professor in dermatology at UCLA in Los Angeles, CA. “It is also non-comedogenic, meaning that squalane does not clog the pores and does not cause you to break out with acne,” he said.

Dr. Garshick added that squalane works by mimicking the body’s natural sebum, providing lightweight, nongreasy hydration. “It helps to moisturize, soften and smooth the skin,” she said. “It also offers antioxidant benefits, protecting the skin from free radical damage, and can help reduce the appearance of fine lines and wrinkles. It helps to maintain the skin’s barrier and prevent dryness without causing irritation.”

Is squalane a good option for people with eczema?

Thanks to its moisturizing and soothing properties, squalane is generally a good option for people with eczema. “Squalane can be beneficial for various types of eczema, including atopic dermatitis and seborrheic dermatitis,” Dr. Garshick said. “Its hydrating properties help manage dryness and support the skin barrier, which is essential in these conditions.”

How do you know if squalane is good for your eczema?

Trial and error is typically the best way to see if squalane helps your eczema. “This would be a matter of trying products that contain squalane to see if it is compatible with your skin,” Dr. Yamauchi said. “One can start with a light formula containing squalane and use heavier, thicker formulas if necessary, depending on how dry your skin is.”

Starting with a patch test is always a good idea, because as with any skincare product, Dr. Garshick cautions that there is a small risk of irritation or allergic reaction. You can consult with a dermatologist if you have concerns, as well as to ask for product suggestions.

There are a few things to look out for when experimenting with squalane for eczema, specifically the skincare product’s formula as a whole. “There are no known risks with squalane for people with eczema since it is derived from squalene, which is naturally produced in our skin,” Dr. Yamauchi said. “However, be sure that the product you use containing squalane does not contain other ingredients you could be sensitive or allergic to, such as parabens.”

How should you add squalane to your skincare routine?

If you want to add squalane into your skincare routine, you can use it in either your morning or evening routine. “It may also be found as an ingredient in various products like cleansers, moisturizers and serums or oils,” Dr. Garshick said. “If in a serum, it is best to apply after cleansing and before moisturizing, or mix a few drops with your moisturizer for enhanced hydration. Follow the general rule of applying products from thinnest to thickest consistency.”

Are there any other things to note about squalane and eczema?

Ultimately, squalane is typically safe for eczema and may help soothe your skin. “Squalane is a versatile and effective skincare ingredient suitable for most skin types, including sensitive and eczema-prone skin,” Dr. Garshick said. “Always choose plant-derived squalane to ensure it is cruelty-free and environmentally friendly.”