Here is an overview of over-the-counter medications for eczema, including topical hydrocortisone and antihistamines.
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Over-the-counter (OTC) medications are products you can purchase on your own and do not require a prescription from a doctor. OTC medications used to treat eczema include hydrocortisone cream and antihistamines, which you can find at a local drugstore.
Topical hydrocortisone is a common OTC treatment for eczema. Topical hydrocortisone is a low-potency steroid cream that works on eczema-prone skin by reducing irritation, itching and inflammation. Topical hydrocortisone comes in many forms, including ointments, creams, lotions and gels to be applied to the skin.
OTC hydrocortisone is usually applied one to four times a day for up to seven days. Follow the directions on the label carefully. Do not use it more often or longer than recommended on the label or by your healthcare provider.
Even though it’s sold over the counter, hydrocortisone products may cause side effects if used inappropriately including:
Antihistamines are medications used to relieve allergy symptoms by blocking the effects of histamine, a chemical released by the immune system during an allergic reaction. They work by binding to histamine receptors, preventing histamine from causing symptoms like itching.
If you have eczema, your healthcare provider may suggest antihistamines to help curb any allergy symptoms you may be experiencing. Antihistamines can also help curb inflammation and provide itch relief.
A healthcare provider may suggest antihistamines to help people with eczema sleep when symptoms are keeping them up at night, as some first-generation antihistamines can cause drowsiness. An example is diphenhydramine, which is found in Benadryl, Siladryl, Unisom, Banophen and Sudafed.
Download a full list of all current FDA-approved treatments for atopic dermatitis, the most common form of eczema.
Medically reviewed on May 6, 2025.